Bone pattern changes in post liver transplant patients using bisphosphonates.

OBJECTIVE: To identify radiographic findings suggestive of drug-induced osteonecrosis and evaluate radiomorphometric patterns indicative of changes in bone mineral density in individuals transplanted for liver disorders using bisphosphonates. STUDY DESIGN: The study group included panoramic x-rays of liver transplant patients who are being monitored and who present a clinical status of osteoporosis and use bisphosphonates. The control group was made up of liver transplant patients who did not have osteoporosis. On panoramic radiographs, mental index (MI) and mandibular cortical index (MCI) and the presence of radiographic anomalies suggestive of osteonecrosis were evaluated. RESULTS: There were significant statistical results when comparing the groups in relation to the decrease in bone mineral density (BMD) with MCI-C3 (p = 0.036), however, there were none in relation to MI (p = 0.14). There were no valid statistical results when relating MCI (p = 0.94) and MI (p = 0.66) with reduced BMD and use of bisphosphonates. CONCLUSION: Liver transplant individuals using bisphosphonates present greater radiographic signs of bone sclerosis suggestive of a greater propensity to develop osteonecrosis of the jaw and an increased risk of presenting changes suggestive of reduced bone mineral density on panoramic radiographs when compared to liver transplant individuals not using bisphosphonates.

Assessment of mandibular cortical index in patients with hepatic cirrhosis: A case-control study.

AIMS: To assess the presence of alterations suggestive of reduced bone mineral density (BMD) by using mandibular cortical index (MCI) in panoramic radiographs of cirrhotic individuals and to evaluate their relationship with other characteristics of hepatic cirrhosis (HC). METHODS AND RESULTS: This is an observational case-control study assessing the medical records of 165 cirrhotic patients matched by sex and age with healthy individuals. MELD (model of end stage liver disease) score, etiology, complications, comorbidities, and serum levels of vitamin D were collected. MCI was used to obtain BMD. Binary logistic regression was used to test associations and the risk estimates were expressed in odds ratio. Most of the sample consisted of men (73.93%) with median age of 56 years old. In the study group, the mean value of MELD was 16.5 and hepatitis C was the main etiology of HC (33.9%). Cirrhotic individuals are 3.99 times more likely to present alterations suggestive of reduced BMD (p < .01). There was no statistical significance in the association of MCI with levels of vitamin D, comorbidities, etiology or cirrhosis complications. CONCLUSIONS: MCI suggestive of reduced BMD is more likely to be identified in panoramic radiographs of cirrhotic individuals than of healthy ones.

Synovial chondromatosis of the temporomandibular joint-clinical, surgical, and imaging findings of a Milgram stage III case series.

Synovial chondromatosis of the temporomandibular joint (TMJ) is a rare disease characterized by cartilaginous metaplasia of the mesenchymal remnants of the synovial membrane with formation of loose cartilaginous nodules. It is prevalent in middle-aged women and the main clinical characteristics are swelling, pain, and limited jaw movements. Diagnosis is difficult, especially in the early stages, because the signs and symptoms are like other TMJ diseases such as internal derangements and tumors. Imaging exams are fundamental in differential diagnosis for detection of synovitis and free cartilaginous bodies. Magnetic resonance imaging with a gadolinium contrast would be of particular interest for this purpose. Treatment involves the removal of the cartilaginous nodules and synovectomy. It can be performed by arthroscopy or arthrotomy depending on the size of the lesion, the number of corpuscles, and the need for auxiliary surgical procedures. Final diagnosis is anatomopathologic. Postoperative follow-up is necessary due to the risk of recurrence.

Fanconi anemia and hematopoietic stem cell transplant as risk factors for oral squamous cell carcinoma: A case report with a 12-year follow-up.

Fanconi anemia is a rare disorder resulting from defects in genes responsible for DNA damage responses. It is characterized by congenital anomalies, aplastic anemia, and a predisposition to cancer. Currently, hematopoietic stem cell transplant (HSCT) is the only curative treatment available for bone marrow failure; however, HSCT increases oral squamous cell carcinoma (OSCC) risk. Here we report the case of a patient diagnosed with Fanconi anemia in childhood who was treated with HSCT and later diagnosed with multiple OSCCs during a 12-year follow-up. Despite multiple surgical interventions and radiotherapy regimens, the patient`s health deteriorated. Management of individuals with Fanconi anemia is challenging and must be provided by a multidisciplinary healthcare team to ensure better staging, treatment planning, and coordination.

Photodynamic therapy in the treatment of oral lesions caused by paracoccidiomycosis.

Paracoccidioidomycosis (PCM) is an endemic disease caused by the dimorphic fungus Paracocdioides brasiliensis and Paracoccidioides lutzii. Oral ulcers are usually the first clinical signs of the disease. As it is a systemic fungal disease, local treatments are considered complementary, such as photodynamic therapy (aPDT). We present a patient with ulcerated lesions in the oral cavity of about 6 months duration. The pain complaint in the oropharynx led to a reduction in food acceptance and a weight loss of around 40 kg. He underwent biopsy of the lip lesion, and the histopathological report described yeast with multiple buds compatible with PMC. Our team opted for treatment with aPDT sessions. Two sessions were carried out in the ward and six in the ICU, showing satisfactory results in the remission of ulcerated lesions associated with PCM as well as the painful symptoms in the oral cavity. Also, the patient underwent Amphotericin B and Sulfamethoxazole-trimethoprim. We believe that the association of aPDT with pharmacological therapy possibly accelerated the repair process of oral lesions, as well as providing fungal lesion decontamination, improving progressively the healing of oral lesions.

Assessment of laboratory tests and intraoperative bleeding in patients with liver cirrhosis undergoing tooth extractions.

OBJECTIVES: The objective of this study was to quantify intraoperative bleeding in patients with cirrhosis and correlate it with clinical characteristics and laboratory coagulation tests. STUDY DESIGN: A case-control study was carried out with 74 patients with cirrhosis who were submitted to preoperative coagulation tests (complete blood count, platelet count, prothrombin time/international normalized ratio, thrombin time, activated partial thrombin time, platelet aggregation, fibrinogen, protein C, protein S, antithrombin, and von Willebrand factor level and activity). The levels of nitrogen compounds that can affect the platelet function were determined in saliva and blood by using automated enzymatic-colorimetric assays. RESULTS: Patients with cirrhosis had changes in almost all coagulation tests. The average volumes of intraoperative bleeding and blood lost per minute in the study group (5.36 mL/min and 0.19 mL/min, respectively) were greater than those in the control group (3.05 mL/min and 0.11 mL/min, respectively; P < .05). In the control group, ascites (P = .012) and presence of periapical lesion (0.034) were positively correlated with bleeding (mL/min). With regard to coagulation tests and nitrogen compounds, only a positively moderate correlation with the platelet aggregation test was observed. CONCLUSIONS: No patients had hemorrhagic events and it was not possible to correlate a greater amount of bleeding with coagulation tests or nitrogen compounds in the study group.

Hospital Dentistry and Dental Care for Patients with Special Needs: Dental approach during COVID-19 Pandemic / Odontologia Hospitalar e Assistência Odontológica para Pacientes com Necessidades Especiais: Abordagem odontológica durante a Pandemia de COVID-19

Introduction: The COVID19 pandemic brought a new panorama for the realization of dental treatment for the general population due to the risk of cross infection in the dental office, aerosol formation and insertion of new personal protective equipment. Emergency and emergency dental criteria were defined to limit the flow of patients in the office in order to improve biosafety conditions among patients. Objective: to describe the dental procedures pertinent to outpatient special care or during hospitalization in the COVID19 pandemic, changes in care and implement biosecurity criteria. Basic procedures: The dental care of the special patient suffers changes, mainly referring to the difficulty of access to the offices, interruption of the conditioning process and difficulty to perform outpatient sedation and sedation with nitrous oxide. Dental care during hospitalization is essential in this patient due to prolonged time of tracheal oro intubation, traumatic oral lesions, preparation of specific oral care protocols, removal of mouth infectious and installation of mouth protectors. Conclusion: Change of care, inclusion of individual protection equipment and new knowledge about the COVID19 allows us to safely assist the patient with special needs both in the dental office and in hospital environment, providing quality of life, oral comfort and reducing oral infections during and after the pandemic. (AU)

Introdução: A pandemia por COVID19 trouxe um novo panorama para a realização do tratamento odontológico para a população em geral devido ao risco de infecção cruzada no consultório odontológico, formação de aerossóis e inserção de novos equipamentos de proteção individual. Critérios de emergência e urgência odontológicos foram definidos para limitar o fluxo de pacientes no consultório com o objetivo de melhoras as condições de biossegurança entre os pacientes. Objetivo: Citar os procedimentos odontológicos pertinentes ao atendimento de paciente com necessidades especiais em âmbito ambulatorial ou hospitalar durante a pandemia por COVID19, alterações nos fluxos de atendimentos e cuidados inerentes a assistência. Procedimentos básicos: O atendimento odontológico do paciente com necessidades especiais sofreu alterações, principalmente referente a dificuldade de acesso aos consultórios, interrupção do processo de condicionamento e dificuldade para a realização de sedação ambulatorial e sedação com óxido nitroso. A assistência odontológica durante a hospitalização por COVID19 é fundamental devido ao tempo prolongado de intubação oro traqueal - lesões orais traumáticas, elaboração de protocolos de cuidados bucais específicos, remoção de focos infecciosos bucais e instalação de protetores bucais. Conclusão: Mudanças nas rotinas de atendimento, inclusão de equipamentos de proteção individual e de novos conhecimentos sobre a COVID19 faz com que possamos atender com segurança o paciente com necessidades especiais tanto no consultório odontológico quando em ambiente hospitalar, proporcionando qualidade de vida, conforto oral e redução das infecções bucais durante e após a pandemia. (AU)

Analgesic and adjuvant anesthetic effect of submucosal tramadol after mandibular third molar surgery.

OBJECTIVE: The aim of this study was to assess analgesic and adjuvant anesthetic effects of submucosal tramadol after third molar extraction. STUDY DESIGN: In this double-blind, split-mouth, placebo-controlled, single-dose, crossover investigation, 52 patients underwent mandibular third molar extraction under local anesthesia. Surgical side was randomly assigned to submucosal 2 mL 100 mg tramadol injection (group T) or normal saline solution (group P) immediately after surgery. Anesthetic blockade duration, time of intake and amount of analgesic rescue drug, and postoperative pain intensity were recorded immediately after anesthesia cessation and 4, 8, 24, 48, and 72 hours after surgery. Data were submitted to analysis of variance and Wilcoxon tests. RESULTS: Anesthetic blockade duration between groups was similar. Group T took significantly less rescue drug after 72 hours (P = .008). Time elapsed before first intake of rescue drug was longer (P = .006), and pain intensity was significantly lower (P = .001) in group T. CONCLUSIONS: Submucosal tramadol injection after oral surgery improved postoperative analgesia, but did not extend anesthetic action duration.

Uso do acesso intraoral para tratamento cirúrgico de hipertrofia bilateral do músculo masseter / Intraoral approach for surgical treatment of bilateral masseter muscle hypertrophy

A hipertrofia do músculo masseter é uma condição incomum, caracterizada pelo aumento do volume do músculo masseter, em grande parte dos casos está associado a um esporão ósseo na região do ângulo mandibular, causando a projeção deste. A etiologia de tal condição é desconhecida, podendo ser atribuída a hábitos parafuncionais, desordens psiquiátricas e da articulação temporomandibular. De diagnóstico clínico, exames complementares são indicados para excluir possíveis patologias que acometem a região parotídeo-massetérica. Diversas formas de tratamento são descritos na literatura como o tratamento clínico-medicamentoso e aplicações de toxina botulínica tipo A Em relação ao tratamento cirúrgico, várias técnicas foram propostas, diferenciando-se basicamente em relação ao tipo de tecido abordado: muscular, ósseo ou ambos e quanto ao acesso utilizado: intra ou extraoral.

The masseter muscle hypertrophy is arare condition characterized by a increased muscle size. In most cases is associated with abone spur leading to a prominent mandibular angle. The etiology is uncertain, usually associated with parafunctional habits, psychiatric illness and disorders of the temporomandibular joint. Diagnosis is clinic but complementary exams are necessary to exclude other pathologies frequent in parotid masseteric region. Many ways of treatment are described in the literature such as the clinic treatment, medicamentous treatment and botulinic toxin type A injection and finally the surgical treatment. This last therapeutic methoa has several techniques that basically differ from each other by the kind of tissue that is manipulated: muscle, osseous or both and about the approach: intra or extra oral may be chosen.

Efficacy of low-level laser therapy and aluminum hydroxide in patients with chemotherapy and radiotherapy-induced oral mucositis.

This study evaluated the efficacy of low-level laser therapy (LLLT) and aluminum hydroxide (AH) in the prevention of oral mucositis (OM). A prospective, comparative and non-randomized study was conducted with 25 patients with head and neck cancer subjected to radiotherapy (RT) or radiochemotherapy (RCT). Twelve patients received LLLT (830 nm, 15 mW, 12 J/cm²) daily from the 1st day until the end of RT before each sessions during 5 consecutive days, and the other 13 patients received AH 310 mg/5 mL, 4 times/day, also throughout the duration of RT, including weekends. OM was measured using an oral toxicity scale (OTS) and pain was measured using the visual analogue scale (VAS). EORTC questionnaires were administered to the evaluate impact of OM on quality of life. The LLLT group showed lower mean OTS and VAS scores during the course of RT. A significant difference was observed in pain evaluation in the 13th RT session (p=0.036). In both groups, no interruption of RT was needed. The prophylactic use of both treatments proposed in this study seems to reduce the incidence of severe OM lesions. However, the LLLT was more effective in delaying the appearance of severe OM.

Efficacy of low-level laser therapy and aluminum hydroxide in patients with chemotherapy and radiotherapy-induced oral mucositis

This study evaluated the efficacy of low-level laser therapy (LLLT) and aluminum hydroxide (AH) in the prevention of oral mucositis (OM). A prospective, comparative and non-randomized study was conducted with 25 patients with head and neck cancer subjected to radiotherapy (RT) or radiochemotherapy (RCT). Twelve patients received LLLT (830 nm, 15 mW, 12 J/cm²) daily from the 1st day until the end of RT before each sessions during 5 consecutive days, and the other 13 patients received AH 310 mg/5 mL, 4 times/day, also throughout the duration of RT, including weekends. OM was measured using an oral toxicity scale (OTS) and pain was measured using the visual analogue scale (VAS). EORTC questionnaires were administered to the evaluate impact of OM on quality of life. The LLLT group showed lower mean OTS and VAS scores during the course of RT. A significant difference was observed in pain evaluation in the 13th RT session (p=0.036). In both groups, no interruption of RT was needed. The prophylactic use of both treatments proposed in this study seems to reduce the incidence of severe OM lesions. However, the LLLT was more effective in delaying the appearance of severe OM.

Este estudo avaliou a eficácia da terapia do laser de baixa potência (LBP) e hidróxido de alumínio (HA) na prevenção da mucosite oral (MO). Um estudo prospectivo, comparativo e não-aleatorizado foi conduzido com 25 pacientes com câncer de cabeça e pescoço submetidos a radioterapia (RT) ou radioquimioterapia (RT/QT). Doze pacientes receberam LBP (830 nm, 15 mW, 12 J/cm²) diariamente desde o primeiro dia até o final da RT antes de cada sessão durante 5 dias consecutivos, e os outros 13 pacientes receberam HA 310 mg/5 mL, 4 vezes ao dia, também por toda a duração da RT, incluindo finais de semana. MO foi mensurada usando uma escala de toxicidade oral (ETO) e dor foi mensurada usando a escala visual analógica (EVA). Questionários da EORTC foram administrados para a avaliação do impacto da MO na qualidade de vida. O grupo LBP mostrou menores médias dos escores da ETO e EVA durante o curso da RT. Uma diferença significante foi observada na avaliação da dor na 13ª sessão de RT (p=0,036). Em ambos os grupos, nenhuma interrupção da RT foi necessária. O uso profilático de ambos os tratamentos propostos neste estudo parece reduzir a incidência de lesões severas de MO. No entanto, o LBP foi mais efetivo no atraso do aparecimento da MO severa.

Osteonecrose bilateral na maxila induzida por zolendronato / Zoledronate-induced maxillary bilateral osteonecrosis

Os bifosfonatos são drogas utilizadas com diversas finalidades, dentre elas, o tratamento da hipercalcemia secundária a neoplasias malignas. Embora sua eficácia médica seja comprovada, o número de pacientes que apresentam osteonecrose nos maxilares vem aumentando devido ao uso desse medicamento. Este relato mostra o tratamento de um paciente que desenvolveu osteonecrose de maxila após fazer uso crônico de bifosfonato, enfatizando o surgimento de lesões maxilares agressivas concomitantes à piora do estado geral do paciente.

Bisphosphonates are drugs used to treat malignat hypercalcemia in certain types of cancer. Although this drug has clear evidence of medical efficacy, there are an increasing number of patients that develop bisphosphonate associated osteonecrosis of the jaws. This report show the treatment of a patient that present osteonecrosis subsequent the cronic use of bisphosphonate showing a strong correlation between the aggressive aspect of the lesion and general health patient.

A prospective study of dentoalveolar trauma at the Hospital das Clínicas, São Paulo University Medical School.

PURPOSE: This prospective study evaluated the profile of patients with dentoalveolar trauma assisted at the emergency room of the Oral and Maxillofacial Trauma and Surgery Service at the Hospital das Clínicas, São Paulo University Medical School (Brazil). METHODS: A prospective study by a questionnaire applied during the first attendance of those patients, in a period of eight months. RESULTS: The collected data were statistically analyzed. It was observed that 4.7% of the patients that sought treatment at the Service had sustained dentoalveolar trauma and among these 74% were male. The most affected individuals were children aged 0 to 5 years and fall was the most prevalent etiologic factor. Avulsion and coronal/crown-root fractures were the most common types of dentoalveolar traumatic injures. As the age increases, the most common etiologic factors are traffic accidents and physical assault. CONCLUSION: The incidence of dentoalveolar trauma decreased with age and the main etiologic factors in adult patients were traffic accidents and physical assault.

A prospective study of dentoalveolar trauma at the Hospital das Clínicas, São Paulo University Medical School

PURPOSE: This prospective study evaluated the profile of patients with dentoalveolar trauma assisted at the emergency room of the Oral and Maxillofacial Trauma and Surgery Service at the Hospital das Clínicas, São Paulo University Medical School (Brazil). METHODS: A prospective study by a questionnaire applied during the first attendance of those patients, in a period of eight months. RESULTS: The collected data were statistically analyzed. It was observed that 4.7 percent of the patients that sought treatment at the Service had sustained dentoalveolar trauma and among these 74 percent were male. The most affected individuals were children aged 0 to 5 years and fall was the most prevalent etiologic factor. Avulsion and coronal/crown-root fractures were the most common types of dentoalveolar traumatic injures. As the age increases, the most common etiologic factors are traffic accidents and physical assault. CONCLUSION: The incidence of dentoalveolar trauma decreased with age and the main etiologic factors in adult patients were traffic accidents and physical assault.

PROPOSIÇÃO: Avaliar o perfil dos pacientes, com traumatismo dento-alveolar, atendidos no Pronto-Socorro do Serviço de Cirurgia e Traumatologia Buco-Maxilo-Facial do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (Brasil). MÉTODOS: Foi realizado um estudo prospectivo, através de um questionário aplicado, durante o primeiro atendimento desses pacientes, em um período de oito meses. RESULTADOS: Os dados obtidos foram analisados estatisticamente e verificou-se que dos pacientes atendidos 4,7 por cento apresentavam traumatismo dento-alveolar, e destes, 74 por cento eram do gênero masculino; as crianças de 0 a 5 anos eram as mais acometidas, a etiologia mais comum foi a queda; e o tipos de traumas mais freqüentes foram a avulsão e fratura dental. A medida que a idade avança os fatores etiológicos mais comuns são os acidentes de trânsito e as agressões físicas. CONCLUSÃO: A incidência de trauma de dentoalveolar diminuiu com a idade e o principal fator etiologico nos pacientes adulto foi acidentes de tráfico e agressão física.